genetics

The five-year project funded by the National Institute of Allergy and Infectious Diseases will involve three projects to investigate factors that accelerate and prevent the re-emergence of HIV.

A UCLA-led study finds that the so-called “selfish” gene acts to remove cholesterol from blood vessels.

Their technique would enable an average biochemistry laboratory to make its own sequences for only about $2 per gene, far less than the $50 to $100 per gene commercial vendors charge.

A UCLA-led analysis identifies brain measures of major psychiatric disease. Researchers also pinpointed important differences in these disorders’ gene expression.

The scientists identified factors that can set the stage for disorders like schizophrenia, depression and ADHD that appear later in life.

UCLA geneticist Dr. Wayne Grody UCLA geneticist says many people are ill-equipped to handle troubling medical information without the guidance of physicians.

The research determined that many early symptoms of the disease can be completely corrected when the relevant genetic defect is turned off.

The process could help restore dystrophin, the protein missing in the muscles of boys with Duchenne muscular dystrophy.

The analysis had a 93 percent accuracy rate for forecasting the chance of survival in people with advanced cardiac disease.

The award from the John Templeton Foundation will help researchers address how much power individuals have over their own health.

The study suggests a new possible framework for treating people with familial hypercholesterolemia, an inherited condition characterized by extremely high levels of LDL, the so-called “bad cholesterol.”

UCLA researchers’ study using zebrafish shows how the disease turns a repair mechanism into one that damages nerve cells. The findings could lead to treatments to prevent nerve damage in leprosy and other diseases.

Professor Douglas Black and colleagues found that not all protein aggregates in brain cells are toxic.

UCLA was among the first medical centers to use exome sequencing, which can analyze more than 20,000 genes at once.

An international team led by researchers from UCLA and Massachusetts General Hospital helped lead discovery of the first definitive genetic mutations.

UCLA researchers observed that mice with a form of autism had an inability to adapt to repeated whisker stimulation.

UCLA research findings show changes in same genes that clipped the sea bird’s wings cause human bone disorders.

Deletions or duplications of DNA along 22nd chromosome hint at biological underpinnings of these neuropsychiatric disorders.

The finding represents one of the clearest examples to date of the phenomenon — stretches of DNA that exist for no reason other than promoting their own inheritance — at the molecular level.

CancerLocator, developed by UCLA researchers, was superior in detecting cancer in blood samples containing low levels of target DNA, which reflect early-stage disease.

Adenosine deaminase-deficient severe combined immunodeficiency is a rare and life-threatening condition that can be fatal within the first year of life if left untreated.

The researchers identified genes that they believe control hundreds of other genes linked to Alzheimer’s disease, Parkinson’s disease, depression and several other disorders.

UCLA School of Nursing researchers found that people with a certain genetic variation who took donepezil for the condition had a faster cognitive decline than those who took a placebo.

The device, developed by UCLA’s Aydogan Ozcan and colleagues in Sweden, could be manufactured for less than $500 each — far less expensive than the equipment that labs use for the same tests.

Neuroscientists at UCLA have developed a new technique for studying a particular type of cell in the brain known as an astrocyte that may play a role in diseases such as Lou Gehrig’s disease and Alzheimer's disease.